Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis
Identifieur interne : 000798 ( Main/Exploration ); précédent : 000797; suivant : 000799Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis
Auteurs : George K. Bertsias [Grèce] ; Maria Tektonidou [Grèce] ; Zahir Amoura [France] ; Martin Aringer [Allemagne] ; Ingeborg Bajema [Pays-Bas] ; Jo H M. Berden [Pays-Bas] ; John Boletis [Grèce] ; Ricard Cervera [Espagne] ; Thomas Dörner [Allemagne] ; Andrea Doria [Italie] ; Franco Ferrario [Italie] ; Jürgen Floege [Allemagne] ; Frederic A. Houssiau [Belgique] ; John P A. Ioannidis [États-Unis] ; David A. Isenberg [Royaume-Uni] ; Cees G M. Kallenberg [Pays-Bas] ; Liz Lightstone [Royaume-Uni] ; Stephen D. Marks [Royaume-Uni] ; Alberto Martini [Italie] ; Gabriela Moroni [Italie] ; Irmgard Neumann [Autriche] ; Manuel Praga [Espagne] ; Matthias Schneider [Allemagne] ; Argyre Starra [Grèce] ; Vladimir Tesar [République tchèque] ; Carlos Vasconcelos [Portugal] ; Ronald F. Van Vollenhoven [Suède] ; Helena Zakharova [Russie] ; Marion Haubitz [Allemagne] ; Caroline Gordon [Royaume-Uni] ; David Jayne [Royaume-Uni] ; Dimitrios T. Boumpas [Grèce]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2012-11.
Abstract
Objectives To develop recommendations for the management of adult and paediatric lupus nephritis (LN). Methods The available evidence was systematically reviewed using the PubMed database. A modified Delphi method was used to compile questions, elicit expert opinions and reach consensus. Results Immunosuppressive treatment should be guided by renal biopsy, and aiming for complete renal response (proteinuria <0.5 g/24 h with normal or near-normal renal function). Hydroxychloroquine is recommended for all patients with LN. Because of a more favourable efficacy/toxicity ratio, as initial treatment for patients with class III–IVA or A/C (±V) LN according to the International Society of Nephrology/Renal Pathology Society 2003 classification, mycophenolic acid (MPA) or low-dose intravenous cyclophosphamide (CY) in combination with glucocorticoids is recommended. In patients with adverse clinical or histological features, CY can be prescribed at higher doses, while azathioprine is an alternative for milder cases. For pure class V LN with nephrotic-range proteinuria, MPA in combination with oral glucocorticoids is recommended as initial treatment. In patients improving after initial treatment, subsequent immunosuppression with MPA or azathioprine is recommended for at least 3 years; in such cases, initial treatment with MPA should be followed by MPA. For MPA or CY failures, switching to the other agent, or to rituximab, is the suggested course of action. In anticipation of pregnancy, patients should be switched to appropriate medications without reducing the intensity of treatment. There is no evidence to suggest that management of LN should differ in children versus adults. Conclusions Recommendations for the management of LN were developed using an evidence-based approach followed by expert consensus.
Url:
- https://api.istex.fr/document/8118FED86673B333CAEB71273726CAB5C32FF93C/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465859
DOI: 10.1136/annrheumdis-2012-201940
Affiliations:
- Allemagne, Autriche, Belgique, Espagne, France, Grèce, Italie, Pays-Bas, Portugal, Royaume-Uni, Russie, République tchèque, Suède, États-Unis
- Angleterre, Berlin, Bohême centrale, Californie, Catalogne, Communauté de Madrid, District de Cologne, District de Dresde, District fédéral central, Grand Londres, Groningue (province), Gueldre, Hollande-Méridionale, Lombardie, Midlands de l'Ouest, Rhénanie-du-Nord-Westphalie, Région de Bruxelles-Capitale, Saxe (Land), Svealand, Vienne (Autriche)
- Aix-la-Chapelle, Barcelone, Berlin, Birmingham, Bruxelles, Dresde, Groningue, Leyde, Londres, Madrid, Milan, Moscou, Nimègue, Paris, Prague, Stockholm, Vienne (Autriche)
- University College de Londres, Université de Birmingham, Université de Groningue
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Bertsias</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medicine, Rheumatology, Clinical Immunology and Allergy, University of Crete, Iraklion</wicri:regionArea><wicri:noRegion>Iraklion</wicri:noRegion></affiliation></author><author><name sortKey="Tektonidou, Maria" sort="Tektonidou, Maria" uniqKey="Tektonidou M" first="Maria" last="Tektonidou">Maria Tektonidou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Internal Medicine, Rheumatology, University of Athens, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, French National Reference Center for SLE, Université Paris VI Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aringer, Martin" sort="Aringer, Martin" uniqKey="Aringer M" first="Martin" last="Aringer">Martin Aringer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Rheumatology, Department of Medicine III, University Medical Center Carl Gustav Carus, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Bajema, Ingeborg" sort="Bajema, Ingeborg" uniqKey="Bajema I" first="Ingeborg" last="Bajema">Ingeborg Bajema</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Berden, Jo H M" sort="Berden, Jo H M" uniqKey="Berden J" first="Jo H M" last="Berden">Jo H M. Berden</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Boletis, John" sort="Boletis, John" uniqKey="Boletis J" first="John" last="Boletis">John Boletis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Nephrology and Transplantation Center, Laiko General Hospital, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Cervera, Ricard" sort="Cervera, Ricard" uniqKey="Cervera R" first="Ricard" last="Cervera">Ricard Cervera</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Autoimmune Diseases, Hospital Clínic, Universitat de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Dorner, Thomas" sort="Dorner, Thomas" uniqKey="Dorner T" first="Thomas" last="Dörner">Thomas Dörner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, Rheumatology and Clinical Immunology, Charité—University Medicine Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Doria, Andrea" sort="Doria, Andrea" uniqKey="Doria A" first="Andrea" last="Doria">Andrea Doria</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Rheumatology, Department of Medicine, University of Padova, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Ferrario, Franco" sort="Ferrario, Franco" uniqKey="Ferrario F" first="Franco" last="Ferrario">Franco Ferrario</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Nephropathology Center, San Gerardo Hospital, Monza and Milan Bicocca University, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Floege, Jurgen" sort="Floege, Jurgen" uniqKey="Floege J" first="Jürgen" last="Floege">Jürgen Floege</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Houssiau, Frederic A" sort="Houssiau, Frederic A" uniqKey="Houssiau F" first="Frederic A" last="Houssiau">Frederic A. Houssiau</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Bruxelles</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P A" last="Ioannidis">John P A. Ioannidis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Department of Medicine, and Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Isenberg, David A" sort="Isenberg, David A" uniqKey="Isenberg D" first="David A" last="Isenberg">David A. Isenberg</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Rheumatology Research, Division of Medicine, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Kallenberg, Cees G M" sort="Kallenberg, Cees G M" uniqKey="Kallenberg C" first="Cees G M" last="Kallenberg">Cees G M. Kallenberg</name><affiliation wicri:level="4"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Lightstone, Liz" sort="Lightstone, Liz" uniqKey="Lightstone L" first="Liz" last="Lightstone">Liz Lightstone</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Section of Renal Medicine, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marks, Stephen D" sort="Marks, Stephen D" uniqKey="Marks S" first="Stephen D" last="Marks">Stephen D. Marks</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Pediatria II, Reumatologia, IRCCS Istituto G Gaslini, Università di Genova, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Moroni, Gabriela" sort="Moroni, Gabriela" uniqKey="Moroni G" first="Gabriela" last="Moroni">Gabriela Moroni</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Divisione di Nefrologia e Dialisi Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Neumann, Irmgard" sort="Neumann, Irmgard" uniqKey="Neumann I" first="Irmgard" last="Neumann">Irmgard Neumann</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Nephrology, Internal Medicine, Wilhelminenspital, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Praga, Manuel" sort="Praga, Manuel" uniqKey="Praga M" first="Manuel" last="Praga">Manuel Praga</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Nephrology Division, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schneider, Matthias" sort="Schneider, Matthias" uniqKey="Schneider M" first="Matthias" last="Schneider">Matthias Schneider</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine, Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Starra, Argyre" sort="Starra, Argyre" uniqKey="Starra A" first="Argyre" last="Starra">Argyre Starra</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Patient representative (Iraklio), Rethymnon</wicri:regionArea><wicri:noRegion>Rethymnon</wicri:noRegion></affiliation></author><author><name sortKey="Tesar, Vladimir" sort="Tesar, Vladimir" uniqKey="Tesar V" first="Vladimir" last="Tesar">Vladimir Tesar</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Nephrology, First School of Medicine, Charles University, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Vasconcelos, Carlos" sort="Vasconcelos, Carlos" uniqKey="Vasconcelos C" first="Carlos" last="Vasconcelos">Carlos Vasconcelos</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>Unidade de Imunologia Clinica, Hospital Santo Antonio, Centro Hospitalar do Porto, UMIB-ICBAS, Universidade do Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Zakharova, Helena" sort="Zakharova, Helena" uniqKey="Zakharova H" first="Helena" last="Zakharova">Helena Zakharova</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Nephrology Unit, Moscow City Hospital n.a. S.P. Botkin, Moscow State Medicine and Dentistry University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Haubitz, Marion" sort="Haubitz, Marion" uniqKey="Haubitz M" first="Marion" last="Haubitz">Marion Haubitz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology and Hypertension, Hannover Medical School, Hannover and Klinikum Fulda, Fulda</wicri:regionArea><wicri:noRegion>Fulda</wicri:noRegion><wicri:noRegion>Fulda</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Caroline" sort="Gordon, Caroline" uniqKey="Gordon C" first="Caroline" last="Gordon">Caroline Gordon</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, West Midlands</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Boumpas, Dimitrios T" sort="Boumpas, Dimitrios T" uniqKey="Boumpas D" first="Dimitrios T" last="Boumpas">Dimitrios T. Boumpas</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Medicine, Rheumatology, Clinical Immunology and Allergy, University of Crete, Iraklion</wicri:regionArea><wicri:noRegion>Iraklion</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2012-11">2012-11</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1771">1771</biblScope></imprint><idno type="ISSN">0003-4967</idno></series><idno type="istex">8118FED86673B333CAEB71273726CAB5C32FF93C</idno><idno type="DOI">10.1136/annrheumdis-2012-201940</idno><idno type="href">annrheumdis-71-1771.pdf</idno><idno type="ArticleID">annrheumdis-2012-201940</idno><idno type="PMID">22851469</idno><idno type="local">annrheumdis;71/11/1771</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives To develop recommendations for the management of adult and paediatric lupus nephritis (LN). Methods The available evidence was systematically reviewed using the PubMed database. A modified Delphi method was used to compile questions, elicit expert opinions and reach consensus. Results Immunosuppressive treatment should be guided by renal biopsy, and aiming for complete renal response (proteinuria <0.5 g/24 h with normal or near-normal renal function). Hydroxychloroquine is recommended for all patients with LN. Because of a more favourable efficacy/toxicity ratio, as initial treatment for patients with class III–IVA or A/C (±V) LN according to the International Society of Nephrology/Renal Pathology Society 2003 classification, mycophenolic acid (MPA) or low-dose intravenous cyclophosphamide (CY) in combination with glucocorticoids is recommended. In patients with adverse clinical or histological features, CY can be prescribed at higher doses, while azathioprine is an alternative for milder cases. For pure class V LN with nephrotic-range proteinuria, MPA in combination with oral glucocorticoids is recommended as initial treatment. In patients improving after initial treatment, subsequent immunosuppression with MPA or azathioprine is recommended for at least 3 years; in such cases, initial treatment with MPA should be followed by MPA. For MPA or CY failures, switching to the other agent, or to rituximab, is the suggested course of action. In anticipation of pregnancy, patients should be switched to appropriate medications without reducing the intensity of treatment. There is no evidence to suggest that management of LN should differ in children versus adults. Conclusions Recommendations for the management of LN were developed using an evidence-based approach followed by expert consensus.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>Russie</li><li>République tchèque</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Bohême centrale</li><li>Californie</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>District de Dresde</li><li>District fédéral central</li><li>Grand Londres</li><li>Groningue (province)</li><li>Gueldre</li><li>Hollande-Méridionale</li><li>Lombardie</li><li>Midlands de l'Ouest</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région de Bruxelles-Capitale</li><li>Saxe (Land)</li><li>Svealand</li><li>Vienne (Autriche)</li></region><settlement><li>Aix-la-Chapelle</li><li>Barcelone</li><li>Berlin</li><li>Birmingham</li><li>Bruxelles</li><li>Dresde</li><li>Groningue</li><li>Leyde</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Moscou</li><li>Nimègue</li><li>Paris</li><li>Prague</li><li>Stockholm</li><li>Vienne (Autriche)</li></settlement><orgName><li>University College de Londres</li><li>Université de Birmingham</li><li>Université de Groningue</li></orgName></list><tree><country name="Grèce"><noRegion><name sortKey="Bertsias, George K" sort="Bertsias, George K" uniqKey="Bertsias G" first="George K" last="Bertsias">George K. Bertsias</name></noRegion><name sortKey="Boletis, John" sort="Boletis, John" uniqKey="Boletis J" first="John" last="Boletis">John Boletis</name><name sortKey="Boumpas, Dimitrios T" sort="Boumpas, Dimitrios T" uniqKey="Boumpas D" first="Dimitrios T" last="Boumpas">Dimitrios T. Boumpas</name><name sortKey="Starra, Argyre" sort="Starra, Argyre" uniqKey="Starra A" first="Argyre" last="Starra">Argyre Starra</name><name sortKey="Tektonidou, Maria" sort="Tektonidou, Maria" uniqKey="Tektonidou M" first="Maria" last="Tektonidou">Maria Tektonidou</name></country><country name="France"><noRegion><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name></noRegion></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Aringer, Martin" sort="Aringer, Martin" uniqKey="Aringer M" first="Martin" last="Aringer">Martin Aringer</name></region><name sortKey="Dorner, Thomas" sort="Dorner, Thomas" uniqKey="Dorner T" first="Thomas" last="Dörner">Thomas Dörner</name><name sortKey="Floege, Jurgen" sort="Floege, Jurgen" uniqKey="Floege J" first="Jürgen" last="Floege">Jürgen Floege</name><name sortKey="Haubitz, Marion" sort="Haubitz, Marion" uniqKey="Haubitz M" first="Marion" last="Haubitz">Marion Haubitz</name><name sortKey="Schneider, Matthias" sort="Schneider, Matthias" uniqKey="Schneider M" first="Matthias" last="Schneider">Matthias Schneider</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Bajema, Ingeborg" sort="Bajema, Ingeborg" uniqKey="Bajema I" first="Ingeborg" last="Bajema">Ingeborg Bajema</name></region><name sortKey="Berden, Jo H M" sort="Berden, Jo H M" uniqKey="Berden J" first="Jo H M" last="Berden">Jo H M. Berden</name><name sortKey="Kallenberg, Cees G M" sort="Kallenberg, Cees G M" uniqKey="Kallenberg C" first="Cees G M" last="Kallenberg">Cees G M. Kallenberg</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Cervera, Ricard" sort="Cervera, Ricard" uniqKey="Cervera R" first="Ricard" last="Cervera">Ricard Cervera</name></region><name sortKey="Praga, Manuel" sort="Praga, Manuel" uniqKey="Praga M" first="Manuel" last="Praga">Manuel Praga</name></country><country name="Italie"><noRegion><name sortKey="Doria, Andrea" sort="Doria, Andrea" uniqKey="Doria A" first="Andrea" last="Doria">Andrea Doria</name></noRegion><name sortKey="Ferrario, Franco" sort="Ferrario, Franco" uniqKey="Ferrario F" first="Franco" last="Ferrario">Franco Ferrario</name><name sortKey="Martini, Alberto" sort="Martini, Alberto" uniqKey="Martini A" first="Alberto" last="Martini">Alberto Martini</name><name sortKey="Moroni, Gabriela" sort="Moroni, Gabriela" uniqKey="Moroni G" first="Gabriela" last="Moroni">Gabriela Moroni</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Houssiau, Frederic A" sort="Houssiau, Frederic A" uniqKey="Houssiau F" first="Frederic A" last="Houssiau">Frederic A. Houssiau</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P A" last="Ioannidis">John P A. Ioannidis</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Isenberg, David A" sort="Isenberg, David A" uniqKey="Isenberg D" first="David A" last="Isenberg">David A. Isenberg</name></region><name sortKey="Gordon, Caroline" sort="Gordon, Caroline" uniqKey="Gordon C" first="Caroline" last="Gordon">Caroline Gordon</name><name sortKey="Jayne, David" sort="Jayne, David" uniqKey="Jayne D" first="David" last="Jayne">David Jayne</name><name sortKey="Lightstone, Liz" sort="Lightstone, Liz" uniqKey="Lightstone L" first="Liz" last="Lightstone">Liz Lightstone</name><name sortKey="Marks, Stephen D" sort="Marks, Stephen D" uniqKey="Marks S" first="Stephen D" last="Marks">Stephen D. Marks</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Neumann, Irmgard" sort="Neumann, Irmgard" uniqKey="Neumann I" first="Irmgard" last="Neumann">Irmgard Neumann</name></region></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Tesar, Vladimir" sort="Tesar, Vladimir" uniqKey="Tesar V" first="Vladimir" last="Tesar">Vladimir Tesar</name></region></country><country name="Portugal"><noRegion><name sortKey="Vasconcelos, Carlos" sort="Vasconcelos, Carlos" uniqKey="Vasconcelos C" first="Carlos" last="Vasconcelos">Carlos Vasconcelos</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name></region></country><country name="Russie"><region name="District fédéral central"><name sortKey="Zakharova, Helena" sort="Zakharova, Helena" uniqKey="Zakharova H" first="Helena" last="Zakharova">Helena Zakharova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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